Each medication used to treat tuberculosis can have adverse effects. Common isoniazid side effects include numbness and tingling in your hands and feet, weakness, loss of appetite, and an upset stomach, nausea, or vomiting. For ethambutol, side effects may include loss of appetite, headache, confusion, painful or swollen joints, chills, abdomen pain, nausea, and vomiting.
Side effects of pyrazinamide include lack of energy, loss of appetite, nausea, vomiting, and muscle or joint pain. For rifampin, side effects may be a skin rash, inflamed pancreas, diarrhea, loss of appetite, nausea, vomiting, or an upset stomach.